Depositional record of a Pliocene nested multivent maar complex at Fekete-hegy, Pannonian Basin, western Hungary.

No abstract availabl

Magnetic characteristics of the Ság-hegy volcanic complex, little Hungarian Plain

The Ság-hegy volcanic complex is located in the little Hungarian Plain Volcanic Field (LHPVF). An 39Ar/ 40Ar geochronolgy gave an isochron age of 5,42 ±0,06 My for the Ság- hegy (Wijbrans et al. 2004). Evolution of the volcano included two clearly distinct events. At first ascending magma entered meteoric water in a fluvio-lacustrine environment. Fuel-coolant interaction (FCI) of water (water saturated sediment) and magma led to the formation of a phreatomagmatic tuff ring. After water supply was used up the interior of the tephra ring was filled by a lava lake. Locally the tuff ring wall collapsed and subsequently lava was able to flow out of the tuff ring. Due to intensive quarrying most of the effusive rocks have been removed, giving excellent insight to emplacement processes of feeder dykes, sills and lava lake remnant (Martin and Németh, 2004). Pyroclastic rocks include massive and bedded units of lapilli stone, lapilli tuff/ tuff as well as pyroclastic breccias. Varying proportions of accidental lithic clasts indicate excavation of basement rocks during the erruption. Juvenile clasts comprise mainly of angular, blocky sideromelane glass shards with nearly equent shapes and a minor proportion of tachylite. A high amount of water within the systeme is evidenced by soft sediment deformation and accretionary lapilli in the pyroclastic bedsets. Dune and antidune bedding, chute and pool structures grading and sorting features suggest that the tuff ring was gradually built up by base surge and intercalated fallout deposits. Subsequent to the phreatomagmatic stage the inner crater has been filled with a lava lake which morphology was determined by the tephra deposits. At contacts to the pyroclastics a chilled margin of several cm thickness is developed which shows platty (onion shaped) jointing. A high number of dykes and sills were injected into adjacent bedsets. These shallow intrusive bodys can be found throughout the whole complex truncating and dissecting the pyroclastic units. In cases where pyroclastic units comprised a high amount of water this included even mingling with the wet tephra, leading to the formation of peperites. The uppermost units were represented by thick lava flows, which covered all underlaying units. These rocks were quarryed out already a century ago except a large strombolian spatter cone which is now exposed at the uppermost level of the quarry as a big sliced remnant including its large multiple feeder dyke. This setting offers a perfect opportunity to study the relationship between dyke and sill enplacement with transitions from vertical to bedding-parallel geometries. Dimensions of the volcanic bodies range from cm thickness of small apophyses from the lava lake into the pyroclastic rocks up to dykes and sills of several m. We performed a detailed study on a section of pyroclastic rocks truncated by dykes and sills and have evaluated the magnetic characteristics. Preliminary results show that magnetic susceptibility of all the pyroclastic units is in the range of ferrimagnetic susceptibility and varies between 2 to 20 x 10-3 SI. (Fig.1). Magnetic fabric anisotropy is generally low (< 5 %) and in the field of oblate fabric geometries, in bedded tuffs a significantly higher (5 to 10 %) but also oblate anisotropy is realized. Magnetic lineations indicate a consistent NE (020) directed material transport for the whole succession. Remanence intensities are quite high with values of 1 to 15 A/m In the pyroclastic units a stable magnetic remanence characterized by a single vector component has been measured, MDF values are in the range of 30 to 160 mT. The field vector has exclusively reversed polarity and steep inclination, which is in agreement with the paleofield direction and therefore is regarded as natural remanent magnetization aquired during deposition of the pyroclastic successions. In the dykes and sills, however, remanence direction scatter significantly and display geometries ranging from steep to flat orientations and show also strong variations in the declination. Coercitivity of magnetic carriers is significanty lower as indicated by the lower MDF values which are in the range of 8 to 30 mT in the dykes and 15 to 30 mT in sills. Beside a minor contribution of a viscose component the remanence vector in the dykes and sills is characterized by a stable single component. However, further investigations are needed to fully understand and interpret the result

Cardiovascular effects of intravenous vatinoxan (MK-467) in medetomidine-tiletamine-zolazepam anaesthetised red deer (Cervus elaphus)

Objective To determine the effect of intravenous vatinoxan administration on bradycardia, hypertension and level of anaesthesia induced by medetomidine-tiletamine-zolazepam in red deer (Cervus elaphus). Study design and animals A total of 10 healthy red deer were enrolled in a randomized, controlled, experimental, crossover study. Methods Deer were administered a combination of 0.1 mg kg-1 medetomidine hydrochloride and 2.5 mg kg-1 tiletamine-zolazepam intramuscularly, followed by 0.1 mg kg-1 vatinoxan hydrochloride or equivalent volume of saline intravenously (IV) 35 minutes after anaesthetic induction. Heart rate (HR), mean arterial blood pressure (MAP), respiration rate (fR), end-tidal CO2 (PE′CO2), arterial oxygen saturation (SpO2), rectal temperature (RT) and level of anaesthesia were assessed before saline/vatinoxan administration (baseline) and at intervals for 25 minutes thereafter. Differences within treatments (change from baseline) and between treatments were analysed with linear mixed effect models (p <0.05). Results Maximal (81 ± 10 beats minute-1) HR occurred 90 seconds after vatinoxan injection and remained significantly above baseline (42 ± 4 beats minute-1) for 15 minutes. MAP significantly decreased from baseline (122 ± 10 mmHg) to a minimum MAP of 83 ± 6 mmHg 60 seconds after vatinoxan and remained below baseline until end of anaesthesia. HR remained unchanged from baseline (43 ± 5 beats minute-1) with the saline treatment, while MAP decreased significantly (112 ± 16 mmHg) from baseline after 20 minutes. PE′CO2, fR, and SpO2 showed no significant differences between treatments, while RT decreased significantly 25 minutes after vatinoxan. Level of anaesthesia was not significantly influenced by vatinoxan. Conclusion and clinical relevance Vatinoxan reversed hypertension and bradycardia induced by medetomidine without causing hypotension or affecting the level of anaesthesia in red deer. However, the effect on HR subsided 15 minutes after vatinoxan IV administration. Vatinoxan has the potential to reduce anaesthetic side effects in non-domestic ruminants immobilized with medetomidine-tiletamine-zolazepam.Peer reviewe

Expression of Cyclins A, E and Topoisomerase II α correlates with centrosome amplification and genomic instability and influences the reliability of cytometric S-phase determination

BACKGROUND: The progression of normal cells through the cell cycle is meticulously regulated by checkpoints guaranteeing the exact replication of the genome during S-phase and its equal division at mitosis. A prerequisite for this achievement is synchronized DNA-replication and centrosome duplication. In this context the expression of cyclins A and E has been shown to play a principal role. RESULTS: Our results demonstrated a correlation between centrosome amplification, cell cycle fidelity and the level of mRNA and protein expression of cyclins A and E during the part of the cell cycle defined as G1-phase by means of DNA content based histogram analysis. It is shown that the normal diploid breast cell line HTB-125, the genomically relatively stable aneuploid breast cancer cell line MCF-7, and the genomically unstable aneuploid breast cancer cell line MDA-231 differ remarkably concerning both mRNA and protein expression of the two cyclins during G1-phase. In MDA-231 cells the expression of e.g. cyclin A mRNA was found to be ten times higher than in MCF-7 cells and about 500 times higher than in HTB-125 cells. Topoisomerase II α showed high mRNA expression in MDA compared to MCF-7 cells, but the difference in protein expression was small. Furthermore, we measured centrosome aberrations in 8.4% of the MDA-231 cells, and in only 1.3% of the more stable aneuploid cell line MCF-7. MDA cells showed 27% more incorporation of BrdU than reflected by S-phase determination with flow cytometric DNA content analysis, whereas these values were found to be of the same size in both HTB-125 and MCF-7 cells. CONCLUSIONS: Our data indicate that the breast cancer cell lines MCF-7 and MDA-231, although both DNA-aneuploid, differ significantly regarding the degree of cell cycle disturbance and centrosome aberrations, which partly could explain the different genomic stability of the two cell lines. The results also question the reliability of cytometric DNA content based S-phase determination in genomically unstable tumor cell populations

Cardiovascular effects of intravenous vatinoxan in wild boars (Sus scrofa) anaesthetised with intramuscular medetomidine-tiletamine-zolazepam

Background The potent sedative medetomidine is a commonly used adjunct for the immobilisation of non-domestic mammals. However, its use is associated with pronounced cardiovascular side effects, such as bradycardia, vasoconstriction and decreased cardiac output. We investigated the effects of the peripherally-acting alpha-2-adrenoceptor antagonist vatinoxan on cardiovascular properties in medetomidine-tiletamine-zolazepam anaesthetised wild boar (Sus scrofa). Methods Twelve wild boars, anaesthetised twice with medetomidine (0.1 mg/kg) and tiletamine/zolazepam (2.5 mg/kg) IM in a randomised, crossover study, were administered (0.1 mg/kg) vatinoxan or an equivalent volume of saline IV (control). Cardiovascular variables, including heart rate (HR), mean arterial blood pressure (MAP), pulmonary artery pressure (PAP), pulmonary artery occlusion pressure (PAOP) and cardiac output (CO), were assessed 5 min prior to vatinoxan/saline administration until the end of anaesthesia 30 min later. Results MAP (p < 0.0001), MPAP (p < 0.001) and MPAOP (p < 0.0001) significantly decreased from baseline after vatinoxan until the end of anaesthesia. HR increased significantly (p < 0.0001) from baseline after vatinoxan administration. However, the effect on HR subsided 3 min after vatinoxan. All variables remained constant after saline injection. There was no significant effect of vatinoxan or saline on CO. Conclusion Vatinoxan significantly reduced systemic and pulmonary artery hypertension, induced by medetomidine in wild boar.Peer reviewe

Magnetische Charakteristik von Pyroklastika des Ság-hegy Vulkan Komplex, Kleine Ungarische Tiefebene

Der Ság-hegy Vulkan Komplex befindet sich in dem Vulkanfeld der Kleinen Ungarischen Tiefebene. Eine 39Ar/40Ar Datierung ergab ein Alter von 5, 42 ± 0, 06Ma für den Ság-hegy (Wijbrans et al. 2004). Die Entwicklung des Vulkans weist zwei verschiedene Ereignisse auf. Als erstes trifft aufsteigendes Magma auf meteorisches Wasser in einer fluviolakustinen Umgebung (fuel-coolant interaction FCI). Die FCI von Wasser bzw. wassergesättigtem Sediment und Magma führte zur Bildung eines phreatomagmatischen Tuffrings. Nachdem das Wasserangebot aufgebraucht war, füllte sich das Innere des Tephrarings mit einem Lavasee. Lokal kollabierte der Tuffring, so dass Lava aus dem See herausfließen konnte. Durch die Anlage eines Steinbruches im zentralen Bereich des Vulkankomplexes ergibt sich ein 3-D Aufschluss mit hervorragenden Einblick auf die Intrusionsbeziehungen von Förderdykes, Sills und Überresten des Lavasees (Martin & Németh, 2004). In dieser Studie sollen die magnetischen Charakteristika einer Sektion von pyroklastischen Gesteinen, die von Dykes und Sills abgeschnitten wird, untersucht werden. Vorläufige Ergebnisse zeigen, dass die magnetische Suszeptibilität aller pyroklastischen Einheiten im Bereich der ferrimagnetischen Suszeptibilität liegt und von (2 − 20 × 10−3 SI variiert...conferenc

Distributed Contact and Identity Management

Contact management is a twofold problem involving a local and global level where the separation between them is rather fuzzy. Locally, users need to deal with contact management, which refers to a local need to store, organize, maintain up to date, and find information that will allow them contacting or reaching other people, organizations, etc. Globally, users deal with identity management that refers to peers having multiple identities (i.e., profiles) and the need of staying in control of them. In other words, they should be able to manage what information is shared and with whom. We believe many existing applications try to deal with this problem looking only at the data level and without analyzing the underlying complexity. Our approach focus on the complex social relations and interactions between users, identifying three main subproblem: (i) management of identity, (ii) search, and (iii) privacy. The solution we propose concentrates on the models that are needed to address these problems. In particular, we propose a Distributed Contact Management System (DCM System) that: Models and represents the knowledge of peers about physical or abstract objects through the notion of entities that can be of different types (e.g., locations, people, events, facilities, organizations, etc.) and are described by a set of attributes; By representing contacts as entities, allows peers to locally organize their contacts taking into consideration the semantics of the contact’s characteristics; By describing peers as entities allows them to manage their different identities in the network, by sharing different views of themselves (showing possibly different in- formation) with different people. The contributions of this thesis are, (i) the definition of a reference architecture that allows dealing with the diversity in relation with the partial view that peers have of the world, (ii) an approach to search entities based on identifiers, (iii) an approach to search entities based on descriptions, and (iv) the definition of the DCM system that instantiates the previously mentioned approaches and architecture to address concrete usage scenarios

Thoracic Electrical Impedance Tomography—The 2022 Veterinary Consensus Statement

Electrical impedance tomography (EIT) is a non-invasive real-time non-ionising imaging modality that has many applications. Since the first recorded use in 1978, the technology has become more widely used especially in human adult and neonatal critical care monitoring. Recently, there has been an increase in research on thoracic EIT in veterinary medicine. Real-time imaging of the thorax allows evaluation of ventilation distribution in anesthetised and conscious animals. As the technology becomes recognised in the veterinary community there is a need to standardize approaches to data collection, analysis, interpretation and nomenclature, ensuring comparison and repeatability between researchers and studies. A group of nineteen veterinarians and two biomedical engineers experienced in veterinary EIT were consulted and contributed to the preparation of this statement. The aim of this consensus is to provide an introduction to this imaging modality, to highlight clinical relevance and to include recommendations on how to effectively use thoracic EIT in veterinary species. Based on this, the consensus statement aims to address the need for a streamlined approach to veterinary thoracic EIT and includes: an introduction to the use of EIT in veterinary species, the technical background to creation of the functional images, a consensus from all contributing authors on the practical application and use of the technology, descriptions and interpretation of current available variables including appropriate statistical analysis, nomenclature recommended for consistency and future developments in thoracic EIT. The information provided in this consensus statement may benefit researchers and clinicians working within the field of veterinary thoracic EIT. We endeavor to inform future users of the benefits of this imaging modality and provide opportunities to further explore applications of this technology with regards to perfusion imaging and pathology diagnosis

Genome-wide Association and Population Genetic Analysis of C-Reactive Protein in African American and Hispanic American Women

C-reactive protein (CRP) is a systemic inflammation marker that predicts future cardiovascular risk. CRP levels are higher in African Americans and Hispanic Americans than in European Americans, but the genetic determinants of CRP in these admixed United States minority populations are largely unknown. We performed genome-wide association studies (GWASs) of 8,280 African American (AA) and 3,548 Hispanic American (HA) postmenopausal women from the Women's Health Initiative SNP Health Association Resource. We discovered and validated a CRP-associated variant of triggering receptors expressed by myeloid cells 2 (TREM2) in chromosomal region 6p21 (p = 10−10). The TREM2 variant associated with higher CRP is common in Africa but rare in other ancestral populations. In AA women, the CRP region in 1q23 contained a strong admixture association signal (p = 10−17), which appears to be related to several independent CRP-associated alleles; the strongest of these is present only in African ancestral populations and is associated with higher CRP. Of the other genomic loci previously associated with CRP through GWASs of European populations, most loci (LEPR, IL1RN, IL6R, GCKR, NLRP3, HNF1A, HNF4A, and APOC1) showed consistent patterns of association with CRP in AA and HA women. In summary, we have identified a common TREM2 variant associated with CRP in United States minority populations. The genetic architecture underlying the CRP phenotype in AA women is complex and involves genetic variants shared across populations, as well as variants specific to populations of African descent

Development, refinement, and validation of an equine musculoskeletal pain scale

Musculoskeletal disease is a common cause of chronic pain that is often overlooked and inadequately treated, impacting the quality of life of humans and horses alike. Lameness due to musculoskeletal pain is prevalent in horses, but the perception of pain by owners is low compared with veterinary diagnosis. Therefore, this study aims to establish and validate a pain scale for chronic equine orthopaedic pain that is user-friendly for horse owners and veterinarians to facilitate the identification and monitoring of pain in horses. The newly developed musculoskeletal pain scale (MPS) was applied to 154 horses (mean age 20 ± 6.4 years SD) housed at an equine sanctuary, of which 128 (83%) suffered from chronic orthopaedic disease. To complete the MPS, the horses were observed and videotaped from a distance while at rest in their box or enclosure. In addition, they received a complete clinical and orthopaedic exam. The need for veterinary intervention to address pain (assessed and executed by the sanctuary independent from this study) was used as a longitudinal health outcome to determine the MPS’s predictive validity. To determine the interrater agreement, the MPS was scored for a randomly selected subset of 30 horses by six additional blinded raters, three equine veterinary practitioners, and three experienced equestrians. An iterative process was used to refine the tool based on improvements in the MPS’s correlation with lameness evaluated at the walk and trot, predictive validity for longitudinal health outcomes, and interrater agreement. The intraclass correlation improved from 0.77 of the original MPS to 0.88 of the refined version (95% confidence interval: 0.8–0.94). The refined MPS correlated significantly with lameness at the walk (r = 0.44, p = 0.001) and trot (r = 0.5, p &lt; 0.0001). The refined MPS significantly differed between horses that needed veterinary intervention (mean MPS = 8.6) and those that did not (mean MPS = 5.0, p = 0.0007). In summary, the MPS showed good interrater repeatability between expert and lay scorers, significant correlation with lameness at the walk and trot, and good predictive validity for longitudinal health outcomes, confirming its ability to identify horses with orthopaedic health problems